Introduction
Viper is used by various research groups, staff and students for biomedical and health science research. Below are some some of the examples users, projects and outputs in this research area.
Groups and Users
The Endothelial Cell Biology in Health and Chronic Disease Research Group
Principal Investigator: Dr Leonid Nikitenko
The Endothelial Cell Biology in Health and Chronic Disease Research Group is dedicated to understanding the contribution of endothelial cells to pathophysiology of chronic diseases. Our basic and clinical laboratory research is focused on characterising properties and molecular mechanisms regulating endothelial cell function in cancer, cardiovascular diseases, lymphoedema and chronic lung disease.
The Endothelial Cell Biology in Health and Chronic Disease Research Group Website
Case Study – Endothelial Cell Research Group
Selected Publications
Harshal Deshmukh, Najeeb Shah, Maria Papageorgiou, Mohammed Altigani Abdalla, Fadel Lhaf, Mo Aye, Thozhukat Sathyapalan, 2022-02, Genetic risk for the polycystic ovary syndrome, bone mineral density and fractures in women and men: A UK Biobank Mendelian randomisation study, Bone, doi: 10.1016/j.bone.2021.116285
Harshal Deshmukh, Emma G. Wilmot, Pratik Choudhary, Parth Narendran, Najeeb Shah, Dennis Barnes, Shafie Kamruddin, Rumaisa Banatwalla, Peter Christian, Simon Saunders, Alistair Lumb, Roselle Herring, Jane Patmore, Chris Walton, Robert E.J. Ryder, Thozhukat Sathyapalan, 2021-09, Impaired Awareness of Hypoglycemia and Severe Hypoglycemia in Drivers With Diabetes: Insights From the Association of British Clinical Diabetologists Nationwide Audit, Diabetes Care, doi: 10.2337/dc21-1181
Deshmukh H, Wilmot EG, Gregory R, Barnes D, Narendran P, Saunders S, Furlong N, Kamaruddin S, Banatwalla R, Herring R, Kilvert A, Patmore J, Walton C, Ryder REJ, Sathyapalan T., 2021-06-29, Predictors of diabetes-related distress before and after FreeStyle Libre-1 use: Lessons from the Association of British Clinical Diabetologists nationwide study, Diabetes, Obesity and Metabolism: A Journal of Pharmacology and Therapeutics, doi: 10.1111/dom.14467
Deshmukh H, Papageorgiou M, Aye M, England J, Abdalla M, Sathyapalan T., 2020-09-18, Hyperthyroidism and bone mineral density: Dissecting the causal association with Mendelian randomization analysis, Clinical Endocrinology, doi: 10.1111/cen.14330
Deshmukh H, Wilmot EG, Gregory R, Barnes D, Narendran P, Saunders S, Furlong N, Kamaruddin S, Banatwalla R, Herring R, Kilvert A, Patmore J, Walton C, Ryder REJ, Sathyapalan T., 2020-07-15, Effect of Flash Glucose Monitoring on Glycemic Control, Hypoglycemia, Diabetes-Related Distress, and Resource Utilization in the Association of British Clinical Diabetologists (ABCD) Nationwide Audit, Diabetes Care, doi: 10.2337/dc20-0738
Donatus O. Onwuli and Sabrina Francesca Samuel and Pagona Sfyri and Kevin Welham and Martin Goddard and Yasir Abu-Omar and Mahmoud Loubani and Francisco Rivero and Antonios Matsakas and David M. Benoit and Mark Wade and John Greenman and Pedro Beltran-Alvarez, 2019-01-31, The inhibitory subunit of cardiac troponin (cTnI) is modified by arginine methylation in the human heart, International Journal of Cardiology, doi: 10.1016/j.ijcard.2019.01.102
Deshmukh, Harshal and Barker, Emma and Ambarasan, Thineshkrishna and Levin, Daniel and Bell, Samira and Witham, Miles D and George, Jacob, 2018-10-29, Calcium channel blockers are associated with improved survival and lower cardiovascular mortality in patients with renovascular disease, Cardiovascular Therapeutics, doi: 10.1111/1755-5922.12474
Deshmukh, Harshal and Papageorgiou, Maria and Kilpatrick, Eric S. and Atkin, Stephen L. and Sathyapalan, Thozhukat, 2018-10-19, Development of a novel risk prediction and risk stratification score for polycystic ovary syndrome, Clinical Endocrinology, doi: 10.1111/cen.13879
Al-Qaissi, Ahmed and Papageorgiou, Maria and Deshmukh, Harshal and Madden, Leigh A. and Rigby, Alan and Kilpatrick, Eric S. and Atkin, Stephen L. and Sathyapalan, Thozhukat, 2018-09-28, Effects of acute insulin-induced hypoglycaemia on endothelial microparticles in adults with and without type 2 diabetes, Diabetes, Obesity and Metabolism, doi: 10.1111/dom.13548
More publications can be found at research-outputs
Selected Preprints
Dimitrios Manolis, Shirin Hasan, Camille Ettelaie, Anthony Maraveyas, Darragh P. O’Brien, Benedikt M. Kessler, Holger Kramer, Leonid L. Nikitenko, 2023-04, Novel protein interaction network of human calcitonin receptor-like receptor revealed by label-free quantitative proteomics, doi: 10.1101/2023.04.18.537143
Eamon C. Faulkner, Adam A. Moverley, Simon P. Hart, Leonid L. Nikitenko, 2023-04, Altered Heterogeneity of Ageing Lung Endothelium is a Hallmark of Idiopathic Pulmonary Fibrosis, doi: 10.1101/2022.03.08.22272025
Selected Grants
Molecular pathways of pancreatic cancer carcinogenesis from pancreatic cystic neoplasms to adenocarcinoma, PI Dr Leonid Nikitenko, The Endothelial Cell Biology in Health and Chronic Disease Research Group, NIHR National Institute for Health Research
EARLY DIAPAC: EARLY DIAgnosis of PAncreatic Cancer by combined proteomics and genomics testing of pancreatic cyst fluid, PI Dr Leonid Nikitenko, The Endothelial Cell Biology in Health and Chronic Disease Research Group, CRUK Cancer Research UK
Quantitative proteomic analysis of pancreatic cyst fluid for early detection of cancer using University of Hull HPC Viper, PI Dr Leonid Nikitenko, The Endothelial Cell Biology in Health and Chronic Disease Research Group, Hull University Teaching Hospitals NHS Trust
TEM-PAC 2: Study of Tumour Regulatory Molecules as Markers of Malignancy in Pancreatic Cystic Lesions – Nikitenko, PI Dr Leonid Nikitenko, The Endothelial Cell Biology in Health and Chronic Disease Research Group, Hull University Teaching Hospitals NHS Trust
ACF 2023-2026, PI Dr Leonid Nikitenko, The Endothelial Cell Biology in Health and Chronic Disease Research Group, NIHR National Institute for Health Research
Selected Postgraduate Completions
Daniel Hardy, Hair Cycle Modulation To Promote Human Wound Healing, Health Sciences, PhD, 2022
Mohammed Altigani Abdalla, Effects of the pharmacological interventions and a structured education in the management of polycystic ovary syndrome (PCOS), Health Sciences (Hull York Medical School), PhD, 2022
Sammi Iveson, Cold Atmospheric Plasma for the Promotion of Wound Healing, Health Sciences (Hull York Medical School), PhD, 2021
Selected Conferences
Eamon Faulkner, Integrated single-cell maps of ageing human lung reveal disease-specific heterogeneity of endothelium in idiopathic pulmonary fibrosis, International Congress on Lung and Airway Fibrosis (iCLAF), October 2022, Reykjavik
Dimitrios Manolis, Label-free quantitative proteomics of pancreatic cyst fluid for early diagnosis of cancer, Pancreatic Cancer UK Discovery and Translational Research Forum, June 2023, Oxford
Adenike Adekeye, Establishing de novo platform for whole genome sequencing of pancreatic cyst fluid for early detection of pancreatic cancer, Pancreatic Cancer UK Discovery and Translational Research Forum, June 2023, Oxford
Leonid L Nikitenko, EARLY DIAPAC Collaborative Study/Consortium: EARLY DIAgnosis of PAncreatic Cancer by ‘multi-omics’ (proteogenomics) analysis of pancreatic cyst fluid, Pancreatic Cancer UK Discovery and Translational Research Forum, June 2023, Oxford
Additional Links
Hull team leads rare cancer study thanks to the late Dr Assem Allam